AJNN
Academic Journal of Neurology and Neurosurgery

The Academic Journal of Neurology and Neurosurgery deals with Neurology and Neurosurgery accepts articles on these topics. Academic Journal of Neurology and Neurosurgery publishes original research articles, review articles, case reports, editorial commentaries, letters to the editor, educational articles, and conference/meeting announcements.

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Original Article
The impact of high dose corticosteroid treatment affect on cardiac abnormalities in patients with multiple sclerosis
Abstract
Aims: High-dose corticosteroids to control acute relapses of multiple sclerosis, leveraging their anti-inflammatory effects. However, these treatments can lead to cardiovascular side effects. Understanding the pathophysiology of corticosteroid induced bradycardia is paramount for healthcare providers. Our aim in this study are to identify risk factors for cardiac side effects and assess the timing of cardiac complications relative to treatment.
Methods: Patients who met the McDonald's criteria for definite MS and patients requiring admission for pulse steroid treatment with an acute recurrence were included.Individuals taking cardiac medications, or with a heart illness were excluded.Patients were given 1 g IV methylprednisolone in 2 hours for five to seven days in order to treat acute relapses.
Results: We studied with 23 patients(6 males and 17 females, 26.1/73.9% respectively).The mean±SD age of the patients was 34.6±9.9 (18-43) years and the mean±SD duration of disease was 5.5±4.9 years.Most of the patients were relapsing–remitting MS in 73.9%, primary progressive in 4.4% and secondary progressive in 21.7%.The most common cardiac arhythmia during corticosteroid pulse therapy was sinus bradycradia(n=6).
Conclusion: The combination of direct effects on cardiac myocytes, electrolyte disturbances, autonomic dysfunction, and individual genetic factors can contribute to the development of bradycardia in MS patients treated with high-dose methylprednisolone. Close monitoring and prompt intervention are crucial to manage this adverse effect and optimize patient safety.

Keywords : Multiple sclerosis, pulse corticosteroid, bradicardia

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Article available in :
Volume 1, Issue 4, 2024
Page : 68-72
https://doi.org/10.51271/AJNN-0016
Article Information
Received : 12 Eyl 2024
Accepted : 17 Eki 2024
Published : 29 Eki 2024
Corresponding Author :

Ceyhun Sayman: Department of Neurology, Alanya Training and Research Hospital, Alaaddin Keykubat University, Antalya, Turkiye

[email protected]
Citation : Sayman C, Güneş S, Türk O, et al. The impact of high dose corticosteroid treatment affect on cardiac abnormalities in patients with multiple sclerosis . Acad J Neurol Neurosurg. 2024;1(4):68-72.

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