AJNN
Academic Journal of Neurology and Neurosurgery

The Academic Journal of Neurology and Neurosurgery deals with Neurology and Neurosurgery accepts articles on these topics. Academic Journal of Neurology and Neurosurgery publishes original research articles, review articles, case reports, editorial commentaries, letters to the editor, educational articles, and conference/meeting announcements.

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Case Report
Third cranial nerve palsy with confirmed HHV-6 positivity
Abstract
We present a rare case of a 38-year-old man diagnosed with third cranial nerve paralysis, where no abnormalities were detected on MRI. Human Herpes Virus-6 (HHV-6) infection affecting the central nervous system and associated with cranial nerve paralysis is an unusual occurrence. This report underscores the importance of considering HHV-6 as a differential diagnosis in patients presenting with cranial nerve palsy and suggests the use of cerebrospinal fluid (CSF) HHV-6 polymerase chain reaction (PCR) testing for confirmation.

Keywords : HHV-6, cranial nerve palsy, human herpes virus, oculamotor nerve palsy

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1. Caserta MT, Mock DJ, Dewhurst S. Human herpesvirus 6. <em>Clin Infect Dis. </em>2001;33(6):829-833.
2. Chencheri N, Dirawi M, Tahir S, Shekhy J, Abuhammour W. The spectrum of neurological manifestations of human herpesvirus 6 infection in children. <em>Cureus</em>. 2021;13(8): e17183
3. Dyson H, Shimeld C, Hill T, Blyth W, Easty D. Spread of herpes simplex virus within ocular nerves of the mouse: demonstration of viral antigen in whole mounts of eye tissue. <em>J Gen Virol. </em>1987;68(12):2989-2995.
4. Eliassen E, Hemond CC, Santoro JD. HHV-6-associated neurological disease in children: epidemiologic, clinical, diagnostic, and treatment considerations. <em>Pediatr Neurol</em>. 2020;105:10-20.
5. Hogestyn JM, Mock DJ, Mayer-Proschel M. Contributions of neurotropic human herpesviruses herpes simplex virus 1 and human herpesvirus 6 to neurodegenerative disease pathology. <em>Neural Regen Res</em>. 2018;13(2):211-221.
6. Papageorgiou E, Ch&rsquo;ng S, Kulkarni A, Anwar S, Empeslidis T. Fourth cranial nerve palsy and bilateral acute retinal necrosis following human herpesvirus 6 infection of the central nervous system. <em>Ocul Immunol Inflamm</em>. 2014;22(3):228-232.
7. Prichard MN, Whitley RJ. The development of new therapies for human herpesvirus 6. <em>Curr Opin Virol</em>. 2014;9:148-153.
8. Santpere G, Telford M, Andr&eacute;s-Benito P, Navarro A, Ferrer I. The presence of human herpesvirus 6 in the brain in health and disease. <em>Biomolecules</em>. 2020;10(11):1520.
9. Skuja S, Svirskis S, Murovska M. Human herpesvirus-6 and-7 in the brain microenvironment of persons with neurological pathology and healthy people. <em>Int J Mol Sci</em>. 2021;22(5):2364.
10. Theil D, Horn AK, Derfuss T, Strupp M, Arbusow V, Brandt T. Prevalence and distribution of HSV-1, VZV, and HHV-6 in human cranial nerve nuclei III, IV, VI, VII, and XII. <em>J Med Virol</em>. 2004;74(1):102-106.
11. Tormanowska M, Dzieciatkowski T, Rynans S, et al. Prevalence of CI-HHV-6 in patients with hematological diseases and healthy donors in Poland-preliminary study. <em>Med Dosw Mikrobiol</em>. 2016;68(2):113-117.
12. Vasilyeva I, Zhdanova V, Chopik N, Makarova T, Galanta E, Tsiubko O. Cranial nerve III and/or VI function abnormalities associated with active herpesvirus infection: Clinical experience and literature review. <em>J Ophthalmol (Ukraine)</em>. 2019;(1):486.
13. You SJ. Human herpesvirus-6 may be neurologically injurious in some immunocompetent children. <em>J Child Neurol</em>. 2020;35(2):132-136.
Article available in :
Volume 1, Issue 4, 2024
Page : 78-80
https://doi.org/10.51271/AJNN-0018
Article Information
Received : 09 Eyl 2024
Accepted : 27 Eyl 2024
Published : 29 Eki 2024
Corresponding Author :

Şeyda Çankaya: Department of Neurology and Clinical Neurosciences, Alanya Alaaddin Keykubat University, Antalya, Turkiye

[email protected]
Citation : Duran U, Sayman D, Özdemir Öktem E, Yuluğ B, Çankaya Ş. Clinical case report: third cranial nerve palsy with confirmed HHV-6 positivity. Acad J Neurol Neurosurg. 2024;1(4):78-80.

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