AJNN
Academic Journal of Neurology and Neurosurgery

The Academic Journal of Neurology and Neurosurgery deals with Neurology and Neurosurgery accepts articles on these topics. Academic Journal of Neurology and Neurosurgery publishes original research articles, review articles, case reports, editorial commentaries, letters to the editor, educational articles, and conference/meeting announcements.

eISSN: 3023-6517
Creative Commons CC BY-NC-ND 4.0 International License.
EndNote Style

Online Manuscript System

Index
Original Article
New onset tremor in patients with COVID-19: can be a possible link with parkinsonism?
Abstract
Aims: SARS-CoV-2 is a highly pathogenic member of the coronavirus family. We notice that some patients who were following in outpatient service have a new onset tremor. Our aim to describe these patients and interpreting new onset tremor after Covid-19 that possible link with parkinsonism.
Methods: Forty-two patients with tremor who applied to Alanya Alaaddin Keykubat University Hospital neurology outpatient clinic between the 2021-2022 years were included the study. The data related to demographic characteristics, reasons for application of outpatient neurology clinic, pre-diagnosis and treatment were collected retrospectively.
Results: The patients had a viral infection up to 3 months before the diagnosis of tremor was examined from the hospital system. It was determined that a total of 7 patients had viral infections due to upper respiratory infections and these were confirmed by polymerase chain reaction (PCR). Since two of these patients had concomitant thyroid dysfunction, one had diabetes and one had a history of acute cerebrovascular disorder, they were not included in the study. Covid-19 results were found to be positive wit PCR in 3 patients with a diagnosis of new onset tremor. It was determined in the neurology outpatient clinic notes of the patients that their complaints started after Covid-19.
Conclusion: We haven’t enough data about Covid-19 yet but it should be included in the differential diagnosis of patients with new onset neurological symptoms, especially in epidemic situations.. Extensive clinical, neurological, and electrophysiological investigations of the patients may help to understand the virus's role in causing neurological manifestations

Keywords : Tremor, COVID-19, parkinsonism

Download Article


1. Fehr AR, Perlman S. Coronaviruses: an overview of their replicationand pathogenesis. In: Maier HJ, Bickerton E, Britton P, eds.Coronviruses: Methods and Protocols. Humana Press: 2015:1-23. doi:10.1007/978-1-4939-2438-7_1
2. Weiss SR, Leibowitz JL. Coronavirus pathogenesis. Advances Virus Res.2011;81:85-164. doi: 10.1016/B978-0-12-385885-6.00009-2
3. Malik YS, Sircar S, Bhat S, et al. Emerging novel coronavirus (2019-nCoV) current scenario, evolutionary perspective based on genomeanalysis and recent developments. Veterinary Quarterly. 2020;40(1): 68-76. doi: 10.1080/01652176.2020.1727993
4. Cheng ZJ, Shan J. 2019 Novel coronavirus: where we are and what weknow. Infection. 2020;48(2):155-163. doi: 10.1007/s15010-020-01401-y
5. Zhou P, Yang XL, Wang XG, et al. A pneumonia outbreakassociated with a new coronavirus of probable bat origin. Nature.2020;579(7798):270-273. doi: 10.1038/s41586-020-2012-7
6. Mao L, Wang M, Chen S, et al. Neurological manifestations ofhospitalized patients with COVID-19 in Vuhan, China: a retrospectivecase series study. MedRxiv. 2020. doi: 10.1101/2020.02.22.20026500
7. Wang L, Shen Y, Li M, et al. Clinical manifestations and evidence ofneurological involvement in 2019 novel coronavirus SARS-CoV-2: asystematic review and meta analysis. J Neurol. 2020;267:2777-2789. doi:10.1007/s00415-020-09974-2
8. Karadaş Ö, Öztürk B, Sonkaya AR. A prospective clinical study ofdetailed neurological manifestations in patients with COVID-19.Neurol Sci. 2020;41(8):1991-1995. doi: 10.1007/s10072-020-04547-7
9. Moriguchi T, Harii N, Goto J, et al. A first case of meningitis/encephalitis associated with SARS-Coronavirus-2. Int J Infect Dis.2020;94:55-58. doi: 10.1016/j.ijid.2020.03.062
10. Giacomelli A, Pezzati L, Conti F, Bernacchia D, Siano M, Oreni L,Rusconi S, Gervasoni C, Ridolfo AL, Rizzardini G, Antinori S, Galli M.Self-reported olfactory and taste disorders in patients with severe acuterespiratory coronavirus 2 infection: a cross-sectional study. Clin InfectDis. 2020;71(15):889-890. doi: 10.1093/cid/ciaa330.
11. Limphaibool N, Iwanowski P, Holstad MJV, Kobylarek D, Kozubski W.Infectious etiologies of parkinsonism: pathomechanisms and clinicalimplications. Front Neurol. 2019;10:652. doi: 10.3389/fneur.2019.00652
12. Donoghue M, Hsieh F, Baronas E, et al. A novel angiotensin-convertingenzyme-related carboxypeptidase (ACE2) converts angiotensin I toangiotensin 1-9. Circ Res. 2000;87(5):e1-e9. doi: 10.1161/01.res.87.5.e1
13. Martin D, Xu J, Porretta C, Nichols CD. Neurocytometry: flowcytometric sorting of specific neuronal populations from human androdent brain. ACS Chem Neurosci. 2017;8(2):356-367. doi: 10.1021/acschemneuro.6b00374
14. Baig AM, Khaleeq A, Ali U, Syeda H. Evidence of the COVID-19virus targeting the CNS: tissue distribution , host − virus interaction, and proposed neurotropic mechanisms. ACS Chem Neurosci.2020;11(7):995-998. doi: 10.1021/acschemneuro.0c00122
15. Ding Y, He LI, Zhang Q, et al. Organ distribution of severe acuterespiratory syndrome (SARS) associated coronavirus (SARS-CoV) inSARS patients: implications for pathogenesis and virus transmissionpathways. J Pathol. 2004;203(2):622-630. doi: 10.1002/path.1560
16. Pan W, Stone PK, Hsuchou H, Manda KV, Zhang Y, Kastin, JA.Cytokine signaling modulates blood-brain barrier function. CurrPharm Des. 2011;17(33):3729-3740. doi: 10.2174/138161211798220918
17. Dubé M, Le Coupanec A, Wong AHM, Rini JM, Desforges M, TalbotPJ. Axonal transport enables neuron-to-neuron propagation of humancoronavirus OC43. J Virol. 2018;92(17):e00404-18. doi: 10.1128/JVI.00404-18
18. Desforges M, Le Coupanec A, Dubeau P, et al. Human coronavirusesand other respiratory viruses: underestimated opportunistic pathogensof the central nervous system? Viruses. 2020;12(1):14. doi: 10.3390/v12010014
19. Hughes JM, Wilson ME, Sejvar JJ. The long-term outcomes of humanWest Nile virus infection. Clin Infect Dis. 2007;44(12):1617-1624. doi:10.1086/518281.
20. Jang H, Boltz DA, Webster RG, Smeyne RJ. Viral parkinsonism.Biochimica Biophysica Acta (BBA)-Molecul Basis Dis. 2009;1792(7):714-721. doi: 10.1016/j.bbadis.2008.08.001
21. Netland J, Meyerholz DK, Moore S, Cassell M, Perlman S. Severe acuterespiratory syndrome coronavirus infection causes neuronal death inthe absence of encephalitis in mice transgenic for human ACE2. J Virol.2008;82(15):7264-7275. doi: 10.1128/JVI.00737-08
22. Fazzini E, Fleming J, Fahn S. Cerebrospinal fluid antibodies tocoronavirus in patients with Parkinson’s disease. Mov Disord.1992;7(2):153-158. doi: 10.1002/mds.870070210
23. Rodriguez-Perez AI, Garrido-Gil P, Pedrosa MA, et al. Angiotensintype 2 receptors: role in aging and neuroinflammation in thesubstantia nigra. Brain Behav Immun. 2020;87:256-271. doi: 10.1016/j.bbi.2019.12.011
24. Arlehamn CSL, Garretti F, Sulzer D, Sette A. Roles for the adaptiveimmune system in Parkinson’s and Alzheimer’s diseases. Curr OpinImmunol. 2019;59:115-120. doi: 10.1016/j.coi.2019.07.004
25. Agrawal U, Raju R, Udwadia ZF. Favipiravir: a new and emergingantiviral option in COVID-19. Med J Armed Forces India.2020;76(4):370-376. doi: 10.1016/j.mjafi.2020.08.004
Article available in :
Volume 1, Issue 1, 2024
Page : 1-4
https://doi.org/10.51271/AJNN-0001
Article Information
Received : 20 Kas 2023
Accepted : 08 Oca 2024
Published : 31 Oca 2024
Corresponding Author :

Ceyhun Sayman: Department of Neurology, Alanya Training and Research Hospital, Alaaddin Keykubat University, Antalya, Turkiye

[email protected]
Citation : Sayman C, Pul MF. New onset tremor in patients with COVID-19: can be a possible link with parkinsonism?. Acad J Neurol Neurosurg. 2024;1(1):1-4.

Read: 284
Cited: 0
Download : 126
_Footer